Investigating the protective effects of cinnamon bark hydroalcoholic extract on the inhibition of liver damage induced by rifampin in male Wistar rats

Introduction: Rifampin is one of the common drugs used to treat tuberculosis and considered a strong toxic agent for liver. The aim this study investigate effects cinnamon extract administration on rifampin-induced hepatotoxicity in rats. Materials methods: In experimental study, 60 male Wistar rats were randomly divided into 6 groups. Liver damage induction oxidative stress caused by 80 mg/kg/day rifampin. Different doses (50, 100 200 mg/kg) administered sick mice daily gavage three rifampin was evaluated examining serum biochemical factors as well amount reactive oxygen species, glutathione, antioxidant capacity, lipid peroxidation histopathological changes liver tissue. Data analysis done using Prism version software one-way variance Tukey's post hoc test. Results: at rate mg/kg 21 consecutive days (P<0.05). On other hand, different could significantly improve consumption (P<0.05) Discussion conclusion: According results with properties protects against These healing shown form reduction markers serum, improvement tissue damage.